Understanding Profiler Results

I have been using v9 to profile my web application. It has really helped focus on the parts of our code that we poorly written (not by me!!!), and I have been tweaking it all. I've now got to the position where profiler only tells me that it is MVC (v4) that is the hot part of the site now.
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Is there any way to establish what I can do to work out how to improve this side, as there is still an issue under load when the site is slow to respond.

Cheers
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